Cilmiga bayoolojiga iyo daawaynta hidda-wadaha ku salaysan AAV ayaa helaya saami badan oo suuqa ah oo lagu daweeyo cudurka.Si kastaba ha ahaatee, horumarinta khad unug naasley ah oo adag oo wax ku ool ah wax soo saarkooda ayaa ah mid adag oo badanaa waxay u baahan yihiin sifo gacanta oo ballaaran.Taariikh ahaan, cytometer socodka waxaa lagu isticmaalaa baaritaannadan unugyada ku salaysan.Si kastaba ha ahaatee, cytometer-ka socodka waa mid aad qaali u ah wuxuuna ku lug leeyahay tababar ballaaran oo loogu talagalay hawlgalka iyo dayactirka labadaba.Dhawaan, iyada oo la kordhinayo awoodda xisaabinta iyo dareemayaasha kamaradaha tayada sare leh, cytometry ku salaysan sawirka ayaa la cusboonaysiiyay si ay u bixiso beddel sax ah oo kharash-ool ah oo loogu talagalay horumarinta habka khadka unugyada.Shaqadan, waxaan ku qeexnay qulqulka shaqada ee horumarinta khadka gacanta oo ay kujirto cytometer-ku-saleysan, oo ah Countstar Rigel, ee qiimeynta hufnaanta wareejinta iyo qiimeynta barkada xasilloon iyadoo la adeegsanayo unugyada CHO iyo HEK293 oo muujinaya antibody iyo rAAV vector, siday u kala horreeyaan.Labada daraasadood, waxaan ku muujinnay:
- Countstar Rigel wuxuu bixiyay saxnaanta ogaanshaha la midka ah ee socodka cytometry.
- Qiimaynta barkada ku salaysan Countstar Rigel waxay kaa caawin kartaa go'aaminta kooxda la rabo ee cloning hal unug (SCC).
- Countstar Rigel oo lagu daray madal horumarinta khadka gacanta ayaa gaadhay 2.5 g/L mAb titer.
Waxaan sidoo kale ka wada hadalnay suurtagalnimada isticmaalka Countstar sida lakab kale oo bartilmaameedka hagaajinta ku salaysan ee rAAV DoE.
Faahfaahin dheeraad ah, fadlan soo deji faylka PDF.
