SCIENTIFIC EVIDENCE

SIGLEC11 promotes M2 macrophage polarization through AKT-mTOR signaling and facilitates the progression of gastric cancer.

Journal for immunotherapy of cancer
Yin J, Lu Y, Liu Y, Shi Q, Shi M, Zhu Z, Fu D, Wang Z, Li C.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
3D Culture
Cancer Research
Immunology
Organoid Culture
Key Finding
The findings showed that SIGLEC11 was predominantly expressed in monocytes and macrophages and selectively upregulated in tumor-associated macrophages. The abundance of SIGLEC11 + M2-like macrophage-infiltrating tumors may serve as a biomarker for identifying immunosuppressive subtypes of GC.
Countstar Connection
For the study samples, researchers obtained cell measurements with Countstar Castor S1 within the 3D-culture workflow for the cancer-model experiments.
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