SCIENTIFIC EVIDENCE

Identification of a Novel Small Molecule STING Agonist Reshaping the Immunomicroenvironment of Pancreatic Ductal Adenocarcinoma.

International journal of biological sciences

Liu P, Shi M, Liu Y, Liu Y, Lin J, Zhai S, Cao Y, Chen D, Jiang Y, Peng C, Zhang L, Ding C, Jiang L, Shen B.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2025

3D Culture

Cancer Research

Immunology

Organoid Culture

Castor S

Key Finding

D166 demonstrated significant anti-tumor activity, effectively activating the cGAS-STING pathway in a time- and dose-dependent manner. Additionally, D166 acted as a sensitizer for anti-PD-1 therapy, significantly improving therapeutic efficacy in combination treatments.

Countstar Connection

Live- and dead-cell count assessment in organoid samples was performed with Countstar Castor S1 within the organoid or 3D-culture workflow.

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