Publications | Countstar Cell Analysis

2024MicrobiologyBioprospectingCell Counter

Global marine microbial diversity and its potential in bioprospecting

Chen J, Jia Y, Sun Y et al. • Nature (2024) | DOI: 10.1038/s41586-024-07891-2

Key FindingGlobal ocean sampling revealed extensive previously uncharacterized microbial genetic diversity and identified bioprospecting candidates, including compact Cas9 systems, antimicrobial peptides, and enzymes with plastic-degradation potential.

Countstar ConnectionCountstar Rigel S2's GFP channel was used to quantify transfection efficiency, supporting functional validation of newly identified Cas9 systems in the marine microbial bioprospecting workflow.

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Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously

Global marine microbial diversity and its potential in bioprospecting

Oxyphenbutazone suppresses non-canonical inflammasome activation and protects against LPS-induced sepsis

DLP-bioprinted ultrabiomimetic trachea with spatiotemporal angiogenesis regulation for segmental airway reconstruction

Integrating phenotypic screening with network pharmacology to explore the potential targets of triterpenoid-enriched fraction from Prunella vulgaris L. in TNBC

Structure-guided sodium butyrate analogs enhance antibody productivity in CHO cells via metabolic and cell-cycle state reprogramming

Oyster cellular architecture and innate immune programs resolved by single-cell RNA sequencing

Orf virus remodels tumor immune microenvironment in melanoma mouse models revealed by single-cell RNA sequencing

A high-modification monophasic hyaluronic acid hydrogel promotes aged-skin regeneration associated with mitochondrial bioenergetic and redox recovery

Single-cell sequencing reveals metabolic reprogramming and immune regulation underlie the maintenance of teleost granulomas

Salinity Modulates Hormetic Responses of the Estuarine Diatom Chaetoceros muelleri to Short-Chain Chlorinated Paraffins: Insights from Physiology and Transcriptomics

Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

Intramuscular self-amplifying RNA and adenoviral RSV vaccines program distinct systemic and respiratory mucosal immune architectures

Establishment of the Bat Adenovirus WIV9 Vector System Using Restriction–Assembly

Nutrient Solution Flow Influences Cell Atlas and Root Morphogenesis in Hydroponic Lettuce Root Growth

Single-cell sequencing reveals the co-option of epithelial structural programs by macrophages in teleost granulomas

Targeting mitochondrial α-ketoglutarate sequestration disables dual oncogenic drivers and metabolic adaptability in pancreatic ductal adenocarcinoma

Paired single-cell profiling reveals epithelial-stromal remodeling after ablative fractional carbon dioxide laser treatment in keloids

A postulation of the acetate metabolic pathway in recombinant CHO cells with high-yield bispecific antibody expression

PDHA1 Hyperactivation Orchestrates Metabolic Reprogramming Promoting Endothelial Senescence

Comprehensive genome editing and signaling pathway engineering evolve potent and safe adenoviral producer cell

The potential of Protaetia brevitarsis as a functional food that enhances immune function and gut microbiota in mice

Bletilla striata polysaccharides promote the proliferation and migration of human gingival fibroblasts on titanium surfaces via the PI3K/AKT pathway: a preliminary in vitro study

SREBP2 promotes macrophage alternative activation and allergic airway inflammation independent of cholesterol biosynthesis

A CHO-Expressed Pseudorabies Virus gD Subunit Vaccine Elicits Potent Neutralizing Antibodies and Confers Complete Protection Against Lethal Challenge in Mice

Network pharmacology, single-cell transcriptomics, machine learning and experimental validation identifying CHEK2 and HPGD as key therapeutic targets of berberine in diabetic nephropathy

Dynamic chromatin regulatory programs of sucrose and citric acid metabolism during fruit ripening in Citrus

Single-cell and spatial transcriptomic profiling reveals distinct immune landscapes in murine lungs infected with H1N1 versus H5N1 influenza viruses

Integrating single-nucleus barcoding with spatial transcriptomics via Stamp-seq to reveal immunotherapy response-enhancing functional modules in NSCLC

AI-Designed TREM1-Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Cellular heterogeneity of hepatic granuloma formation and evolution in murine schistosomiasis japonica

GM-CSF Promotes Neutrophil PD-L1 Expression Through the VEGFR-2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Single-nucleus sequencing dissects the malignant change of early lung adenocarcinoma: SMAD3 suppresses antitumor T cell immunity via ICAM1

Restricting Synaptotagmin-3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re-Programming

Single-cell transcriptomic analysis of the terminal ileum identifies BCMA as a therapeutic target in IgA nephropathy

Down-Regulation of TFEB With Defective Autophagy in the Susceptibility of Aging Kidneys to Septic Acute Kidney Injury

Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling

A single-cell profile of the porcine immune repertoire: concurrent profiling of T cell receptor and B cell receptor V(D)J sequences in health

Dysregulation of the HSF1-Mediated UPRmt Pathway in Colonic Smooth Muscle Cells Drives Motility Dysfunction in Functional Constipation

Anti-Adhesion Effects and Potential Mechanisms of Polyglutamic Acid-Polylysine Crosslinked Hydrogels in a Rat Peritoneal Adhesion Model

Comprehensive Extraction of Shrimp Head Lipids and Peptides from Litopenaeus vannamei: Evaluation of Neuroprotective Potential and Constituent Analysis

HSPA8 globally modulates transcriptome profile and PI3K/AKT signaling pathway to facilitate malignant progression phenotypes of triple-negative breast cancer

Single-cell RNA sequencing reveals PANoptosis signatures of acinar cells, macrophages, and neutrophils during injury and repair in acute pancreatitis

Cross-Species Comparison of Diabetic Skin at Single-Cell Resolution: db/db and STZ Mouse Models Versus Human Diabetic Foot Patients

Single-cell and spatial transcriptomics identify a JUNB+ neutrophil subset enriched in immune-excluded regions of lung adenocarcinoma

Multiplatform single-cell and spatial transcriptomics reveal sex-specific malignant states and architecture in male breast cancer

Single-cell lineage tracing in tumor organoids identifies expansion states depicting the origin and progression of lung adenocarcinoma

Targeting arginine metabolism reverses bone immunosuppressive microenvironment and metastasis in ARID1A-deficient triple negative breast cancer

Ginseng-derived exosomes loaded in fibrin gel promote retinal ganglion cell survival in glaucoma by exerting anti-inflammatory effects through modulating microglial polarization

Macrophage-derived fibronectin suppresses antitumor immunity via tissue stiffening and immunosuppressive cell induction in cancer mouse models

Oral microbiome-metabolome axis links glycerophospholipid dysregulation to Alzheimer's disease

Distinct immune microenvironment in HER2-low triple-negative breast cancer underlies inferior response to immunotherapy

Peroxisomal DBP deficiency causes male infertility through disruption of lipid homeostasis in Drosophila

Preparation and Characterization of Neutrophil Membrane-Fused Mitochondria (nMITO)

Temporal and Cellular Organization of Immune Responses to Live Attenuated Herpes Zoster Vaccination

Multi-omics reveal molecular changes during suspension adaptation of HEK293 cells

The LINC01094 drives atherosclerosis endothelial injury and inflammation via the miR-218-5p/SP1 axis and servers as a clinical biomarker

Insights into volatile flavoromics and microbiomics for sensory quality improvement of flue-cured tobacco leaves fermented with Bacillus subtilis DB-15

Single-cell RNA sequencing reveals lipid metabolism disorders in the retina in spontaneous high myopia

Single-cell landscape of lymphoid and myeloid heterogeneity across type-stratified craniofacial lesions in polyostotic fibrous dysplasia

Nanoengineered GATA3+ Macrophages Transplantation Reconstitutes the Muscle Stem Cells Niche for Skeletal Muscle Regeneration

Faecalibacterium prausnitzii in the gut protects against acute lung injury in influenza through butyrate educated reparative CD4+T cells

Physiology-Mimicking Microfluidic Oxygenator with Good Hemocompatibility for In Vitro Respiratory Support of Preterm Infants

Platelet-derived serotonin epigenetically programs macrophage alternative activation to orchestrate type 2 airway inflammation

Dissecting the angiogenic mechanism of pachychoroid polypoidal choroidal vasculopathy

Targeting Lactate-Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD-1 Blockade

CX3CR1⁺ CD8⁺ cytotoxic T cells drive tumor killing in esophageal squamous cell carcinoma during neoadjuvant therapy

Non-genetically reprogrammed meta-neutrophils potentiate chemo-immunotherapy against lung metastatic triple-negative breast cancer

The IRE1-XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5-HT Dependent Endogenous Anti-Autophagy Mechanism

Pulmonary mRNA-LNP vaccines for rapid and durable protection against bacterial infection

Integrative transcriptomic and single-cell analysis reveals a convergent cholangiocyte-associated host inflammatory program in biliary atresia and SARS-CoV-2-associated hepatobiliary injury

Immunological profiling of rheumatoid factor-positive primary Sjögren's syndrome by single-cell RNA sequencing

Single-nucleus RNA sequencing reveals the pathological process and key transcription factor of sorafenib-induced cardiotoxicity

Application of rapidly prepared nonactivated high-efficiency chimeric antigen receptor T cells in the treatment of bladder cancer

Immune-dominated cellular heterogeneity and stromal plasticity in keloid infiltrating and hypercellular zones revealed by single-cell RNA sequencing

ABCA1-mediated lipid efflux restrains oxidative stress and neuroinflammation after spinal cord injury

Loss of Lepr in Fibroblasts Drives Tumor Development by Promoting Macrophage Infiltration

Spatial and single-nucleus transcriptomic profiling reveal polarity and intracellular responses to mitochondrial dysfunction