ZC3H4 regulates infiltrating monocytes, attenuating pulmonary fibrosis through IL-10.
Respiratory research
Liu Y, Zhang X, Wang J, Yang F, Luo W, Huang J, Chen M, Wang S, Li C, Zhang W, Chao J.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2022
Single-Cell Analysis
No items found.
Key Finding
This study revealed that ZC3H4 regulated the secretion function of monocytes, which, in turn, inhibited fibroblast function in early inflammation through autophagy signaling, thereby reducing pulmonary fibrosis. These findings provide a new idea for the clinical treatment of silicosis.
Countstar Connection
Using Countstar (model not specified), the study assessed cell measurements in cell suspensions before single-cell analysis in the 2022 Respiratory research study.
