Wzi modulates immune evasion of hypervirulent Klebsiella pneumoniae in a CPS-dependent and independent manner.
Virulence
Wei S, Xu T, Xiang Q, Liu J, Li D, Zhang J, Huang L, Liu J, Liu J, Chen Y, Du Q, Zhou K.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2026
Immunology
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Key Finding
Wzi and CPS independently trigger sustained neutrophil recruitment through CXCL1 upregulation, resulting in pulmonary barrier damage and enhanced bacterial systemic dissemination for encapsulated K. pneumoniae. Notably, wzi sequence polymorphisms significantly influenced serum resistance independent of CPS, with hvKP-associated alleles conferring the highest resistance.
Countstar Connection
A Countstar instrument supplied cell-count measurements for the study's cell samples before downstream analysis in the 2026 Virulence study.
