SCIENTIFIC EVIDENCE

Wnt3a promotes in situ dentin formation through NKD1-MSX1 axis-mediated odontogenic differentiation of dental pulp stem cells.

International journal of oral science
Du H, Li Q, Zhou C, Xu J, Gao K, Li Z, Xu Y, Liu O, Li B, Xu J, Wang J, Kagami H, Li X, Chen S, Zhou J.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2026
Single-Cell Analysis
Stem Cell Research
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Key Finding
Murine pulp exposure models validated that Wnt3a-activated NKD1-MSX1 signaling significantly enhances reparative dentin formation. This study delineates an evolutionarily conserved Wnt3a-NKD1-MSX1 axis that resolves stem cell heterogeneity into functional odontoblast commitment, providing both mechanistic insights into dentin-pulp regeneration and a foundation for targeted regenerative therapies.
Countstar Connection
Using Countstar (model not specified), the study assessed cell number and viability in single-cell suspensions before single-cell analysis in the 2026 International journal of oral science study.
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