Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells.
Experimental & molecular medicine
He L, Zhu H, Zhou S, Wu T, Wu H, Yang H, Mao H, SekharKathera C, Janardhan A, Edick AM, Zhang A, Hu Z, Pan F, Guo Z.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2018
Cancer Research
No items found.
Key Finding
Five-fluorouracil-resistant colorectal cancer cells showed increased TCF4 and beta-catenin expression and suppression of CHK1 signaling. The findings linked Wnt-pathway activity, histone deacetylation, and CHK1-pathway inhibition in a mechanism associated with resistance, particularly in p53 wild-type cells.
Countstar Connection
Countstar (model not specified) measured cell numbers in the study's cell samples during growth assessment in the 2018 Experimental & molecular medicine study.
