Up-regulated microRNA-143 in cancer stem cells differentiation promotes prostate cancer cells metastasis by modulating FNDC3B expression.
BMC cancer
Fan X, Chen X, Deng W, Zhong G, Cai Q, Lin T.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2013
Cancer Research
Immunology
Single-Cell Analysis
Stem Cell Research
No items found.
Key Finding
The inhibition of miR-143 increased the expression of FNDC3B protein but not FNDC3B mRNA in vitro and vivo. These data demonstrate for the first time that miR-143 was up-regulated during the differentiation of prostate cancer stem cells and promoted prostate cancer metastasis by repressing FNDC3B expression.
Countstar Connection
Cell-count assessment in the study's cell samples was performed with Countstar (model not specified) during preparation for single-cell or single-nucleus analysis.
