Unveiling the role of PPIF and macrophage subtypes in LSCC progression via single-cell and exosome RNA sequencing.
Scientific reports
Wang J, Liu C, Wu T, Tan L, Wang J, Zhang W, Liu Y, Wei X, Zhang D.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cancer Research
Immunology
Single-Cell Analysis
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Key Finding
This analysis revealed significant heterogeneity among malignant cells, T cells, and macrophages. Further analyses suggested that PPIF up-regulation in Macrophage-C1-C1QC cells was associated with the enhancement of their anti-inflammatory phenotype and the promotion of F11R-F11R signaling with malignant cells, allowing LSCC cells to evade macrophage-mediated cytotoxicity.
Countstar Connection
Cell-count assessment in the study's cell samples used Countstar Rigel S3 before single-cell analysis for the study's single-cell analysis.
