Two-stage induced differentiation of OCT4+/Nanog+ stem-like cells in lung adenocarcinoma.
Oncotarget
Li R, Huang J, Ma M, Lou Y, Zhang Y, Wu L, Chang DW, Zhao P, Dong Q, Wu X, Han B.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2016
Cancer Research
No items found.
Key Finding
The authors observed the induced cells lost stem-like characteristics, regained sensitivity to cisplatin, and displayed reduced tumorigenic capacity. These findings suggest that targeting stem-like cells by reverting them to more specialized state may be an approach to treat lung cancer.
Countstar Connection
Countstar (model not specified) provided the instrument readout for cell numbers in the study's cell samples within the 3D-culture workflow for the cancer-model experiments.
