SCIENTIFIC EVIDENCE

Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status.

Journal of experimental & clinical cancer research: CR
Zhang H, Zhang G, Xiao M, Cui S, Jin C, Yang J, Wu S, Lu X.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2024
Cancer Research
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Key Finding
Mechanistic investigations revealed that wild-type or mutant p53 might guide FOSB to recognize and bind to distinct promoter sequences via protein-protein interactions to transcriptionally activate specific target genes, thereby creating disparate influences on the progression and prognosis in NSCLC.
Countstar Connection
Cell numbers were measured in the study's cell samples with Countstar (model not specified) during growth assessment in the 2024 Journal of experimental & clinical study.
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