SCIENTIFIC EVIDENCE

Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation.

Nature communications
Lin W, Chen L, Zhang H, Qiu X, Huang Q, Wan F, Le Z, Geng S, Zhang A, Qiu S, Chen L, Kong L, Lu JJ.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2023
Cancer Research
Immunology
Single-Cell Analysis
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Key Finding
The study reveals that tumor-intrinsic YTHDF1 drives immune evasion and immune checkpoint inhibitor (ICI) resistance. Additionally, YTHDF1 deficiency converts cold tumors into responsive hot tumors, which improves ICI efficacy. Here, the authors reveal that tumor-intrinsic YTHDF1 drives immune evasion and immune checkpoint inhibitor (ICI) resistance.
Countstar Connection
Countstar (model not specified) measured cell viability in the study's cell samples before single-cell analysis in the 2023 Nature communications study.
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