SCIENTIFIC EVIDENCE

Transcriptional regulation of Rankl by Txnip-Ecd in aging and diabetic related osteoporosis.

Journal of advanced research

Cao X, Liu K, Yuan J, Hua Q, Rong K, Zhou T, He W, Pang Y, Yang X, Yu Y, Zhang P, Ma P, Cao Y, Zhao J, Morahan G, Xu J, Qin A.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2025

Single-Cell Analysis

No items found.

Key Finding

However, factors that participated in the RANKL-related bone remodeling process in primary and secondary osteoporosis are less known. s Revealing the novel transcriptional regulatory mechanism of RANKL is of great significance for the treatment of osteoporosis. The regulatory function of Txnip on Rankl expression was revealed for the first time through the novel transcription-related Ecdysoneless (Ecd)-P300 axis.

Countstar Connection

For the study's cell samples, researchers obtained flow-cytometry measurements with Countstar (model not specified) before single-cell analysis for the reported research.

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