The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency.
Science advances
Hong X, Zhong X, Du G, Hou Y, Zhang Y, Zhang Z, Gong T, Zhang L, Sun X.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2020
Immunology
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Key Finding
The authors fabricated 80-nm MSNs with different pore sizes (7.8 nm, 10.3 nm, and 12.9 nm) and loaded them with ovalbumin antigen. demonstrated these MSNs with different pore sizes were equally effective in the first three steps of the DUMP cascade, but those with larger pores showed higher cross-presentation efficiency (step 4).
Countstar Connection
Countstar (model not specified) supported assessment of cell concentration in the study's cell samples during quality assessment in the 2020 Science advances study.
