The acidic transformed nano-VO 2 causes macrophage cell death by the induction of lysosomal membrane permeabilization and Ca 2+ efflux.
Toxicology reports
Xu S, Xu S, Chen S, Fan H, Luo X, Sun Y, Wang J, Yuan H, Xu A, Wu L.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2015
Immunology
No items found.
Key Finding
The authors conclude that although nVO 2 displays no acute toxicity, its acidic transformation product induces macrophage apoptosis by the induction of LMP and Ca 2+ efflux. This report suggests that the interplay with environmental factors or living organisms can in physicochemical transformation of nanomaterials and the ensuing distinctive biological effects.
Countstar Connection
Cell measurements were assessed in the study's cell samples with a Countstar instrument during sample-quality assessment.
