SCIENTIFIC EVIDENCE

TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation.

Nucleic acids research
Stolz P, Mantero AS, Tvardovskiy A, Ugur E, Wange LE, Mulholland CB, Cheng Y, Wierer M, Enard W, Schneider R, Bartke T, Leonhardt H, Elsässer SJ, Bultmann S.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2022
Immunology
Microbiology
No items found.
Key Finding
In particular, the authors show that TET1 is critical for the establishment of H3K9me3 and H4K20me3 at endogenous retroviral elements (ERVs) and their silencing that is independent of its canonical role in DNA demethylation. In summary, the authors demonstrate that the non-catalytic functions of TET1 are critical for regulation of gene expression and the silencing of endogenous retroviruses in mESCs.
Countstar Connection
Countstar (model not specified) measured cell numbers in the study's cell samples during growth assessment in the 2022 Nucleic acids research study.
View paper ↗
Stay Connected toCountstar Science
Get new publications, application notes, cell analysis insights, and Countstar updates delivered to your inbox.
Meet us online
Products
About Us
Contact
© 2026 Countstar. All rights reserved.