Targeting VEGF signaling and stromal remodeling enhances chemoimmunotherapy efficacy in esophageal cancer.

The authors identified distinct post-treatment accumulation of ACKR1+ endothelial cells (ECs) and CFD+ cancer-associated fibroblasts (CAFs) at tumor boundaries, potentially correlating with enhanced CD8+ T cell infiltration and improved clinical outcomes. These findings could offer novel theoretical insights and actionable strategies for enhancing treatment efficacy in ESCC.

The study's cell samples underwent cell-viability assessment with Countstar (model not specified) during preparation for single-cell or single-nucleus analysis.