SCIENTIFIC EVIDENCE

Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy.

Science advances
Chen YJ, Li GN, Li XJ, Wei LX, Fu MJ, Cheng ZL, Yang Z, Zhu GQ, Wang XD, Zhang C, Zhang JY, Sun YP, Saiyin H, Zhang J, Liu WR, Zhu WW, Guan KL, Xiong Y, Yang Y, Ye D, Chen LL.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2023
Cancer Research
Immunology
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Key Finding
The study shows that IRG1 is expressed in tumor-associated macrophages (TAMs) in both human and mouse tumors. Deletion of Irg1 in mice suppresses the growth of multiple tumor types and enhances the efficacy of anti-PD-(L)1 immunotherapy.
Countstar Connection
The researchers assessed cell concentration, viability, and size in the study's cell samples with Countstar (model not specified) during sample-quality assessment.
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