SCIENTIFIC EVIDENCE

Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma.

British journal of cancer
Meng G, Li B, Chen A, Zheng M, Xu T, Zhang H, Dong J, Wu J, Yu D, Wei J.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2020
Cancer Research
Immunology
Microbiology
No items found.
Key Finding
Interestingly, DCA significantly reduced lactate release, STAT3 activation, IDO1 upregulation, and MDSC infiltration in NDV-treated HCC. Consequently, DCA significantly enhanced the antitumour immune responses, leading to improved antitumour efficacy and prolonged survival in mouse models of ascitic and subcutaneous HCC.
Countstar Connection
Countstar (model not specified) quantified cell number and viability in the study's cell samples during quality assessment in the 2020 British journal of cancer study.
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