Synthetic enhancers including TFREs improve transgene expression in CHO cells.
Heliyon
Liu HN, Wang XY, Zou Y, Wu WB, Lin Y, Ji BY, Wang TY.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2024
Bioprocessing
No items found.
Key Finding
Transcriptomics analysis was performed and found that transcriptional activation and cell cycle regulation genes were involved. Optimization of enhancers in the CMV promoter could increase the production yield of transgene in transfected CHO cells, which has significance for developing high-yield CHO cell expression system.
Countstar Connection
Countstar (model not specified) supported measurement of cell number and viability in the study's cell samples during transfection assessment.
