Sulforaphane reverses gefitinib tolerance in human lung cancer cells via modulation of sonic hedgehog signaling.
Oncology letters
Wang F, Wang W, Li J, Zhang J, Wang X, Wang M.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2018
Cancer Research
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Key Finding
Western blot analysis revealed that the expression of SHH, Smoothened (SMO), zinc finger protein GLI1 (GLI1), GLI2, CD133 and CD44 were upregulated in PC9GT cells, as compared with in PC9 cells. The of the present study demonstrated that SFN inhibits the proliferation of gefitinib-tolerant lung cancer cells via modulation of the SHH signaling pathway.
Countstar Connection
Countstar (model not specified) measured cell numbers in the study's cell samples during growth assessment in the 2018 Oncology letters study.
