SCIENTIFIC EVIDENCE

Stress granule assembly impairs macrophage efferocytosis to aggravate allergic rhinitis in mice.

Nature communications
Zhou Y, Yang Z, Wang Y, Dong Y, Wang T, Li Y, Liang C, Liu Y, Li Z, Liu S, Gui L, Fan Y, Lei T, Jia K, Zhang L, Wang M, Nie W, Chen L, Ma M, Wu Y, Zhong C, Liu H, Hou J.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Immunology
Single-Cell Analysis
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Key Finding
Mechanistically, intracellular m 7 G-modified Lrp1 mRNA, encoding for a typical efferocytosis receptor, is transported by the m 7 G reader QKI7 into stress-induced SGs, where Lrp1 mRNA is sequestered away from the translation machinery, ultimately ing in reduced macrophage efferocytosis.
Countstar Connection
The researchers measured cell viability in the study's cell samples with Countstar (model not specified) before single-cell analysis in the 2025 Nature communications study.
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