Splicing diversity enhances the molecular classification of pituitary neuroendocrine tumors.
Nature communications
Huang Y, Guo J, Han X, Zhao Y, Li X, Xing P, Liu Y, Sun Y, Wu S, Lv X, Zhou L, Zhang Y, Li C, Xie W, Liu Z.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Cancer Research
No items found.
Key Finding
Notably, the authors effectively distinguish the silent corticotroph subtype and define a distinct TPIT lineage subtype, which is associated with worse clinical outcomes and increased splicing abnormalities driven by altered ESRP1 expression.
Countstar Connection
For the study's cell samples, Countstar Rigel S2 provided cell-count and viability measurements during quality assessment in the 2025 Nature communications study.
