SCIENTIFIC EVIDENCE

Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC.

The Journal of biological chemistry
Liu W, Yang J, Fang S, Jiao C, Gao J, Zhang A, Wu T, Tan R, Xu Q, Guo W.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2022
Cell Counting & Viability
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Key Finding
Specifically, while 8A did not reduce NLRP3 oligomerization, the authors found that it inhibited the oligomerization of adaptor protein apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC), as ASC speck formation was significantly reduced.
Countstar Connection
Countstar (model not specified) measured cell numbers in the study's cell samples during quality assessment in the 2022 The Journal of biological chemistry study.
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