SCIENTIFIC EVIDENCE

Spatially resolved single-cell transcriptome analysis of murine Salmonella infection reveals the role of distal colonocytes in the inflammatory response.

Gut microbes
Xu D, Zhang R, Li S, Guo C, Guan C, Li X, Guo M, Xu X, Liu Y, Mao C, Sun P, Dang X, Sun D, Wang C, Bush SJ, Ye K.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Microbiology
Single-Cell Analysis
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Key Finding
Tm), a prominent enteric pathogen that causes human colitis, to establish a murine model of Salmonella enterocolitis. Furthermore, by correlating the findings with human intestinal single-cell transcriptome data, the authors identified a human colonocyte population that shares many characteristics with murine DCCs.
Countstar Connection
Countstar Rigel S2 quantified cell number and viability in cell suspensions before single-cell analysis in the 2025 Gut microbes study.
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