Sorafenib-loaded metal-organic framework nanoparticles for anti-hepatocellular carcinoma effects through synergistically potentiating ferroptosis and remodeling tumor immune microenvironment.

Using orthotopic tumor mouse model and humanized PBMC mouse model, the authors also found that Sor@Fe-MOF obviously activated the anti-HCC immunity via increasing tumor infiltration of CD8 + T cells. Taken together, the findings highlighted the excellent capacity of Sor@Fe-MOF to facilitate ferroptosis and remodel immune microenvironment, consequentially improving therapeutic response of Sor.

Countstar (model not specified) supplied cell-viability measurements for the study's cell samples before single-cell analysis in the 2025 Materials today. Bio study.