SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism.
Neoplasia (New York, N.Y.)
Chen S, Yang X, Yu M, Wang Z, Liu B, Liu M, Liu L, Ren M, Qi H, Zou J, Vucenik I, Zhu WG, Luo J.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2019
Cancer Research
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Key Finding
Acetylation of PYCR1 at K228 reduced its enzymatic activity by impairing the formation of the decamer of PYCR1. As a, acetylation of PYCR1 at K228 inhibits cell proliferation, while deacetylation of PYCR1 mediated by SIRT3 increases PYCR1's activity.
Countstar Connection
The researchers relied on a Countstar instrument to measure cell numbers in the study's cell samples during growth assessment for the cancer-model experiments.
