Acetylation of PYCR1 at K228 reduced its enzymatic activity by impairing the formation of the decamer of PYCR1. As a, acetylation of PYCR1 at K228 inhibits cell proliferation, while deacetylation of PYCR1 mediated by SIRT3 increases PYCR1's activity.
Countstar Connection
The researchers relied on a Countstar instrument to measure cell numbers in the study's cell samples during growth assessment for the cancer-model experiments.
