SCIENTIFIC EVIDENCE

Single-nucleus transcriptomic profiling reveals temporal dynamics of neuroinflammation and myelin repair after intracerebral haemorrhage.

Clinical and translational medicine
Chen Z, Wang Q, Xiang R, Ding R, Tao J, Peng Q, Wang S, Cheng N, Zhao M, Li J, Xue Q, Liu C, Chen X, Liu L, Wang J, Wang J, Wang M.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Immunology
Single-Cell Analysis
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Key Finding
Key points Establish intracerebral haemorrhage (ICH) mouse models at various time points (Days 1, 3, 7, 14, 28) and construct a high-quality single-nucleus RNA sequencing (snRNA-seq) atlas. Computational analyses suggest that macrophage recruitment in the early stage of ICH potentially involves migration inhibitory factor (MIF) signalling pathways.
Countstar Connection
Nuclei numbers were measured in isolated nuclei with Countstar (model not specified) before single-cell analysis in the 2025 Clinical and translational medicine study.
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