SCIENTIFIC EVIDENCE

Single-nucleus RNA sequencing reveals the distinct heterogeneity of primary pulmonary sarcomas (PPS) and pulmonary sarcomatoid carcinoma (PSC).

Clinical and translational medicine
Zhu J, Xiong Y, Ma S, Wei J, Chen J, Wang W, Duan Q, Zhang Q, Chen D, Deng W, Jiang T, Lei J.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2026
Cancer Research
Single-Cell Analysis
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Key Finding
The findings revealed that the majority of cells in PSC were of epithelial origin, while fibroblasts predominated in PPS. Prognostic Driver HMGA2: Elevated HMGA2 in malignant AT2 cells correlates with poor prognosis and is significantly higher in MET-mutated PSC.
Countstar Connection
The study used Countstar Rigel S2 for nuclei-count assessment in isolated nuclei during preparation for single-cell or single-nucleus analysis.
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