SCIENTIFIC EVIDENCE

Single-Nucleus RNA Sequencing and Spatial Transcriptomics Reveal Cellular Heterogeneity and Intercellular Communication Networks in the Hypothalamus-Pituitary-Ovarian Axis of Pregnant Mongolian Cattle.

Animals: an open access journal from MDPI
Bao Y, Ma F, Huo C, Jia H, Li Y, Yang X, Liu J, Gu P, Shi C, Gu M, Zhu L, Wang Y, Liu B, Na R, Zhang W.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Single-Cell Analysis
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Key Finding
Ovarian luteal cells exhibited steroidogenic specialization and microenvironmental synergy: endothelial cells coregulated TGFβ-driven angiogenesis and immune tolerance, while luteal-stromal PRL - PRLR interactions amplified progesterone synthesis and nutrient support. Spatial mapping revealed GCs' annular follicular distribution, mediating oocyte-somatic crosstalk, and luteal-endothelial colocalization supporting vascularization.
Countstar Connection
Researchers used a Countstar instrument to assess nuclei numbers in isolated nuclei before single-cell analysis in the 2025 Animals: an open access journal study.
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