Single nucleus RNA-seq reveals the process from onset to chronic kidney disease in IgA nephropathy.
Scientific reports
You JP, Cheng GY, Zhang XX, Wang Z, Liu C, Ning W, Liu YR, Hu HM, Zhai YL, Qi YY, Zhao ZZ.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Single-Cell Analysis
No items found.
Key Finding
Pathways related to complement activation, focal adhesion, and collagen formation were significantly enhanced in IgAN compared to healthy controls. The authors observed a potential transition from mesangial cells to myofibroblasts within MSCs, accompanied by increased expression of genes involved in complement activation, humoral immunity, collagen organization, and extracellular matrix assembly.
Countstar Connection
Countstar Rigel S2 supported nuclei numbers measurement in isolated nuclei before single-cell analysis for the reported research.
