Single-cell transcriptomic reveals the peritoneal microenvironmental change in long-term peritoneal dialysis patients with ultrafiltration failure.
iScience
Diao X, Zhan C, Ye H, Wu H, Yi C, Lin J, Mao H, Chen W, Yang X.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2024
Immunology
Single-Cell Analysis
Stem Cell Research
No items found.
Key Finding
Single-cell sequencing revealed that peritoneal neutrophils were elevated in LV_UF patients, while MRC1-macrophage subcluster decreased compared with PD patients with short vintage (SV) and LV without ultrafiltration failure (LV_NOT_UF). Additionally, mesenchymal-like MCs and AQP1 expression were reduced in the LV_UF group compared with the other groups.
Countstar Connection
Using Countstar (model not specified), the study measured cell numbers in the study's cell samples during preparation for single-cell or single-nucleus analysis.
