Single-cell transcriptomic landscape of the mid-secretory eutopic endometrium reveals receptivity defects in adenomyosis.

In summary, the findings indicate that excessive proliferation and impaired differentiation of epithelial cells, along with insufficient inflammatory activation and decidualization defects in stromal cells, jointly underlie reduced endometrial receptivity in AM.

Cell viability was assessed in the study's cell samples with Countstar (model not specified) during preparation for single-cell or single-nucleus analysis.