Single-cell transcriptomic analysis of peripheral blood mononuclear cells reveals key immune responses in ST-segment elevation myocardial infarction.
Hereditas
Zhang Z, Wang S, Liu Y, Li G, Cheng Q, Yang W, Yan G, Gao C.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Immunology
Single-Cell Analysis
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Key Finding
CellChat analysis revealed enhanced intercellular communication in STEMI, with the CXCL signaling pathway (notably PF4–CXCR3 interaction) being highly upregulated. This study reveals key inflammatory and immune characteristics of PBMCs in STEMI patients.
Countstar Connection
Countstar Rigel S2 was the instrument used to assess cell concentration and viability in PBMC suspensions during preparation for single-cell or single-nucleus analysis.
