Single-Cell Sequencing Unveils the Heterogeneity of Nonimmune Cells in Chronic Apical Periodontitis.
Frontiers in cell and developmental biology
Lin X, Chi D, Meng Q, Gong Q, Tong Z.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2021
Immunology
Single-Cell Analysis
No items found.
Key Finding
Chronic apical periodontitis (CAP) is a unique dynamic interaction between microbial invasions and host defense mechanisms, resulting in infiltration of immune cells, bone absorption, and periapical granuloma formation. The study presented potential clues that the shift of inflammatory cytokines, chemokines, proteases, and growth factors initiated polymorphic cell differentiation, lymphangiogenesis, and angiogenesis during CAP.
Countstar Connection
Using Countstar (model not specified), the study assessed flow-cytometry cell measurements in the study's cell samples before single-cell analysis in the 2021 Frontiers in cell and developmental study.
