Single-cell sequencing reveals the heterogeneity of pancreatic neuroendocrine tumors under genomic instability and histological grading.

The study analyzed the heterogeneity of tumor cells according to two classification criteria, genomic instability (including CNV alteration and tumor mutation burden) and histological grading. The authors revealed that the activated core pathways of tumor cells were significantly different under different histological grading's and genomic instability patterns.

Researchers used Countstar (model not specified) to assess cell viability in the study's cell samples during preparation for single-cell or single-nucleus analysis.