Single Cell Sequencing Reveals Mechanisms of Persistent Truncus Arteriosus Formation after PDGFRα and PDGFRβ Double Knockout in Cardiac Neural Crest Cells.
Genes
Chen T, Song S, Jiang H, Lian H, Hu S.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2022
Immunology
Single-Cell Analysis
Stem Cell Research
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Key Finding
In addition, the authors further explored the mechanism with single-cell RNA sequencing. The authors found that two main cell differentiation trajectories into vascular smooth muscle cells (VSMCs) from cardiomyocytes (CMs) and mesenchymal cells (MSs), respectively, were interrupted in the DKO group.
Countstar Connection
Countstar (model not specified) supported cell concentration and viability measurement in the study's cell samples before single-cell analysis for the study's single-cell analysis.
