SCIENTIFIC EVIDENCE

Single-cell sequencing reveals immune features of treatment response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma.

Nature communications
Yang Z, Tian H, Chen X, Li B, Bai G, Cai Q, Xu J, Guo W, Wang S, Peng Y, Liang Q, Xue L, Gao S.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2024
Cancer Research
Immunology
Single-Cell Analysis
Stem Cell Research
No items found.
Key Finding
CXCL13 + CD8 + Tex cells, a subset of exhausted CD8 + T cells, are revealed to highly infiltrate in pre-treatment tumors and show prominent progenitor exhaustion phenotype in post-treatment samples from responders. The authors validate CXCL13 + CD8 + Tex cells as a predictor of improved response to nICT and reveal CXCL13 to potentiate anti-PD-1 efficacy in vivo.
Countstar Connection
Countstar Rigel S2 measured cell numbers in the study's cell samples during preparation for single-cell or single-nucleus analysis.
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