Single-cell RNA sequencing profiling of mouse cardiac cells in response to retinoic acid.
Heliyon
Yin Q, Chu Q, Jiang H, Feng J, Lian H, Nie Y, Hu S.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2024
Single-Cell Analysis
No items found.
Key Finding
To elucidate the cardiac cellular and molecular mechanisms of cardiac malformation, the authors administered pregnant mice with a single dose of all-trans retinoic acid (RA) at E8.5, as the CHD model. RA significantly impacted various CM subpopulations, particularly the outflow tract CMs at E9.0 by reduction of Tdgf1 expression.
Countstar Connection
The study measured cell number and viability in the study's cell samples using Countstar (model not specified) before single-cell analysis for the study's single-cell analysis.
