Single-Cell RNA Sequencing Identifies Intra-Graft Population Heterogeneity in Acute Heart Allograft Rejection in Mouse.
Frontiers in immunology
Tang Y, Wang J, Zhang Y, Li J, Chen M, Gao Y, Dai M, Lin S, He X, Wu C, Shi X.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2022
Single-Cell Analysis
No items found.
Key Finding
In the present study, the authors used single-cell RNA sequencing technology to analyze graft-infiltrating cells to describe cell types and states associated with acute rejection in a mouse heart transplant model. Further analysis of this population showed activation of antigen processing and presentation pathway and upregulation of MHC class II molecules.
Countstar Connection
Countstar (model not specified) measured cell viability in the study's cell samples before single-cell analysis in the 2022 Frontiers in immunology study.
