SCIENTIFIC EVIDENCE

Single-Cell Profiling Reveals Conserved Differentiation and Partial EMT Programs Orchestrating Ecosystem-Level Antagonisms in Head and Neck Cancer.

Journal of cellular and molecular medicine
Jiang D, Wu X, Deng Y, Yang X, Wang Z, Tang Y, He L, He X.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Bioprocessing
Cancer Research
Single-Cell Analysis
No items found.
Key Finding
Compartment-specific crosstalk analysis revealed Epi_pEMT cells may coordinate with mCAF1 fibroblasts and TAM(SPP1) through COL1A1-CD44 and SPP1-CD44 signalling, suggesting potential formation of a pro-invasive niche. These axes suggest a potential hierarchical ecology framework where lineage-specific polarisation and inter-compartment synergies may collectively govern disease progression.
Countstar Connection
Countstar (model not specified) measured cell number and viability in the study's cell samples during preparation for single-cell or single-nucleus analysis.
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