Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atrophic gastritis.

The authors observed an immune decline in the mucosal microenvironment during the development of CAG, including a reduced immune response of C1Q + macrophages, reduced cytotoxicity of T cells, and increased infiltration of exhausted T cells.

Countstar Rigel S2 measured cell number and viability in the study's cell samples during preparation for single-cell or single-nucleus analysis.