SCIENTIFIC EVIDENCE

Single-cell profiles delineate immune cell remodeling and enhanced tumor-fibroblast interaction of hepatoblastoma after chemotherapy.

Cell reports. Medicine
Chen D, Zhan Y, Zhou E, Chen H, Dai S, Yang R, Ye C, Wang J, Li Y, Lu Y, Fang Y, Chen L, Yao W, Li K, Zheng S, Dong K, Wang J, Dong R.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2025
Cancer Research
Immunology
Single-Cell Analysis
Stem Cell Research
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Key Finding
A subset of AFP-high hepatic tumor cells expresses high fibroblast growth factor receptor 4 (FGFR4) and showed elevated proliferation. Post-treatment, mesenchymal-like tumor cells and MMP11 + cancer-associated fibroblasts enhance FGF-FGFR signaling.
Countstar Connection
The study's cell samples underwent cell-viability assessment with Countstar (model not specified) before single-cell analysis for the study's single-cell analysis.
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