SCIENTIFIC EVIDENCE

Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype.

Nature communications
Wu XH, He YY, Chen ZR, He ZY, Yan Y, He Y, Wang GM, Dong Y, Yang Y, Sun YM, Ren YH, Zhao QY, Yang XD, Wang LY, Fu CJ, He M, Zhang SJ, Fu JF, Liu H, Jing ZC.

Publication Overview

Key findings, Countstar context, and access to the original paper.
2023
Single-Cell Analysis
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Key Finding
The authors discover an increase in C1 (non-classical) and C2 (intermediate) monocytes in PBMCs and a decrease in hypoxia-inducible transcription factor-1α (HIF-1α) in all monocyte subsets associated with HAPH. In addition, the authors demonstrate that similar immune adaptations may exist in HAPH and PH.
Countstar Connection
Cell-count and viability assessment in the study's cell samples used Countstar (model not specified) before single-cell analysis for the study's single-cell analysis.
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