SETDB1 knockdown boosts recombinant protein in CHO cells via epigenetic transcriptional silencing.
AMB Express
Lu JT, Zhang M, Gao YP, Yang LL, Cui ZM, Han MM, Zhang X, Xu HY, Wang XY, Qiu LL, Hua ZC, Wang TY, Jia YL.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Bioprocessing
Immunology
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Key Finding
SETDB1-knockdown (SETDB1-KD) CHO cells demonstrated significantly enhanced recombinant antibody-specific productivity. This temporal correlation demonstrates that SETDB1-mediated epigenetic regulation is essential for maintaining both recombinant protein titers and chromosomal stability in industrial biomanufacturing processes.
Countstar Connection
The research used Countstar (model not specified) for cell-viability assessment in the study's cell samples during quality assessment for the reported research.
