Quantitative control of noise in mammalian gene expression by dynamic histone regulation.
eLife
Tan D, Chen R, Mo Y, Gu S, Ma J, Xu W, Lu X, He H, Jiang F, Fan W, Wang Y, Chen X, Huang W.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2021
Cell Counting & Viability
No items found.
Key Finding
Simultaneous attenuation of CBP/p300 and HDAC4/5 reduced heterogeneity in the expression of endogenous genes, suggesting that this mechanism is universal. The findings suggest a mechanism for the modulation of noise in synthetic and endogenous gene expression systems.
Countstar Connection
Researchers relied on Countstar (model not specified) for cell-count measurements in the study's cell samples during preparation for single-cell or single-nucleus analysis.
