SCIENTIFIC EVIDENCE

Propofol Protects Myocardium From Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through the AKT/p53 Signaling Pathway

Frontiers in Pharmacology

Shengqiang Li, Zhen Lei, Xiaomei Yang, Meng Zhao, Yonghao Hou, Di Wang, Shuhai Tang, Jingxin Li, Jingui Yu

Publication Overview

Key findings, Countstar context, and access to the original paper.

2022

Cell Counting & Viability

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Key Finding

This myocardial ischemia/reperfusion study evaluated propofol in ferroptosis-related injury. The authors report that propofol reduced injury-associated effects through an AKT/p53-linked mechanism, supporting a role for ferroptosis modulation in the observed cardioprotection.

Countstar Connection

Measured trypan-blue cell viability in H9C2 cardiomyocyte experiments.

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