SCIENTIFIC EVIDENCE

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Shen D, Li R, She Y, Liu X, Huang Y, Ji Y, Chen K, Song Z, Chen R, Li X, Zhao Q, Chen Q, Chen M.

Publication Overview

Key findings, Countstar context, and access to the original paper.

2026

Cancer Research

Immunology

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Key Finding

The findings identify PRDM1 as a key factor associated with nICRT resistance and suggest that targeting ferroptosis pathways or disrupting PRDM1+ cell-mediated immune suppression may represent a viable strategy in ESCC.

Countstar Connection

The study measured cell number and viability in the study's cell samples using Countstar Rigel S2 after sample dissociation for the cancer-model experiments.

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