PPARγ controls ESCRT-dependent fibroblast-like synoviocyte exosome biogenesis and alleviates chondrocyte osteoarthritis mediated by exosomal ANXA1.
Journal of orthopaedic translation
Jia S, Yang Y, Liu J, Wang Z, Bai L.
Publication Overview
Key findings, Countstar context, and access to the original paper.
2025
Bioprocessing
No items found.
Key Finding
As a therapeutic cargo, FLSs exosomal ANXA1 was confirmed be internalization by chondrocyte via exosome labeled experiment and ANXA1 could inhibit the phosphorylation of ERK to activate the autophagy and decrease chondrocyte apoptosis.
Countstar Connection
Cell number and viability were measured in the study's cell samples with Countstar Rigel S2 before single-cell analysis in the 2025 Journal of orthopaedic translation study.
